反应详情

温度

120 °C

A mixture of N-[1-(3-chloro-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide (43 mg) and isopropylamine (0.50 mL) in N-methyl-2-pyrrolidinon (1.50 mL) is stirred at 120° C. for two days. The mixture is concentrated in vacuo and the residue is purified by HPLC on reversed phase (MeOH/H2O/NH4OH). LC (method 5): tR=1.95 min; Mass spectrum (ESI+): m/z=453 [M+H]+.

1. concentrationThe mixture is concentrated in vacuo
2. customthe residue is purified by HPLC on reversed phase (MeOH/H2O/NH4OH)