N-cyclopropyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)piperidin-4-amine → N-Cyclopropyl-4-(4-methyl-oxazol-5-yl)-N-[1-(3-phenyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-benzamide

HRID 68839Notes

Reaction equation

HRID 68839 reaction equation
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[O:15][N:14]=[C:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[CH3:22][C:23]1[N:24]=[CH:25][O:26][C:27]=1[C:28]1[CH:36]=[CH:35][C:31]([C:32](O)=[O:33])=[CH:30][CH:29]=1>>[CH:1]1([N:4]([CH:5]2[CH2:6][CH2:7][N:8]([C:11]3[O:15][N:14]=[C:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[N:12]=3)[CH2:9][CH2:10]2)[C:32](=[O:33])[C:31]2[CH:30]=[CH:29][C:28]([C:27]3[O:26][CH:25]=[N:24][C:23]=3[CH3:22])=[CH:36][CH:35]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 68289604N-cyclopropyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)piperidin-4-amineHCID 682900554-(4-Methyloxazol-5-yl)benzoic acid

Product 1

HCID 68351854N-Cyclopropyl-4-(4-methyl-oxazol-5-yl)-N-[1-(3-phenyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-benzamide

Procedure

The title compound is prepared from cyclopropyl-[1-(3-phenyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amine and 4-(4-methyl-oxazol-5-yl)-benzoic acid following a procedure analogous to that described in Example 17. LC (method 11): tR=3.12 min; Mass spectrum (ESI+): m/z=470 [M+H]+.

Sources & evidence

ORD record
ord-671562f25a214a428941780ede682175
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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