Pyrazinecarbonyl chloride → N-Cyclopropyl-4-oxazol-5-yl-N-[1-(5-pyrazin-2-yl-[1,2,4]oxadiazol-3-yl)-piperidin-4-yl]-benzamide

HRID 68846Notes

Reaction equation

HRID 68846 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([C:24](=[NH:27])[NH:25][OH:26])[CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.[N:28]1[CH:33]=[CH:32][N:31]=[CH:30][C:29]=1[C:34](Cl)=O>>[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([C:24]3[N:27]=[C:34]([C:29]4[CH:30]=[N:31][CH:32]=[CH:33][N:28]=4)[O:26][N:25]=3)[CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 88279Pyrazinecarbonyl chlorideHCID 178513431HCID 178513431, compound

Product 1

HCID 68351859N-Cyclopropyl-4-oxazol-5-yl-N-[1-(5-pyrazin-2-yl-[1,2,4]oxadiazol-3-yl)-piperidin-4-yl]-benzamide

Procedure

The title compound is prepared from N-cyclopropyl-N-[1-(N-hydroxycarbamimidoyl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide and pyrazine-2-carbonyl chloride following a procedure analogous to that described in Example 47. LC (method 2): tR=1.15 min; Mass spectrum (ESI+): m/z=458 [M+H]+.

Sources & evidence

ORD record
ord-99e485d5e7354d09b350ff78f6ef9764
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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