N-(1-Cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide → N-Cyclopropyl-N-{1-[3-(2-hydroxy-1,1-dimethyl-ethyl)-[1,2,4]oxadiazol-5-yl]-piperidin-4-yl}-4-oxazol-5-yl-benzamide

HRID 68854Notes

Reaction equation

HRID 68854 reaction equation
[C:1]([N:3]1[CH2:8][CH2:7][CH:6]([N:9]([CH:23]2[CH2:25][CH2:24]2)[C:10](=[O:22])[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[O:21][CH:20]=[N:19][CH:18]=3)=[CH:13][CH:12]=2)[CH2:5][CH2:4]1)#[N:2].[OH:26][CH2:27][C:28]([CH3:34])([CH3:33])[C:29]([NH:31][OH:32])=N>>[CH:23]1([N:9]([CH:6]2[CH2:5][CH2:4][N:3]([C:1]3[O:32][N:31]=[C:29]([C:28]([CH3:34])([CH3:33])[CH2:27][OH:26])[N:2]=3)[CH2:8][CH2:7]2)[C:10](=[O:22])[C:11]2[CH:12]=[CH:13][C:14]([C:17]3[O:21][CH:20]=[N:19][CH:18]=3)=[CH:15][CH:16]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 86678209N-(1-Cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamideHCID 178450611HCID 178450611, compound

Product 1

HCID 68351858N-Cyclopropyl-N-{1-[3-(2-hydroxy-1,1-dimethyl-ethyl)-[1,2,4]oxadiazol-5-yl]-piperidin-4-yl}-4-oxazol-5-yl-benzamide

Procedure

The title compound is prepared from N-(1-cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide and 3,N-dihydroxy-2,2-dimethyl-propionamidine following a procedure analogous to that described in Example 1. LC (method 1): tR=1.08 min; Mass spectrum (ESI+): m/z=452 [M+H]+.

Sources & evidence

ORD record
ord-9e989f69828a41e4846be1470213c048
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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