2-Chloro-5-ethylpyrimidine → N-Cyclopropyl-N-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-3-fluoro-4-oxazol-5-yl-benzamide

HRID 68858Notes

Reaction equation

HRID 68858 reaction equation
[CH:1]1([N:4]([CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[C:5](=[O:18])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[C:8]([F:17])[CH:7]=2)[CH2:3][CH2:2]1.Cl[C:26]1[N:31]=[CH:30][C:29]([CH2:32][CH3:33])=[CH:28][N:27]=1>>[CH:1]1([N:4]([CH:19]2[CH2:24][CH2:23][N:22]([C:26]3[N:31]=[CH:30][C:29]([CH2:32][CH3:33])=[CH:28][N:27]=3)[CH2:21][CH2:20]2)[C:5](=[O:18])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[C:8]([F:17])[CH:7]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 35727632-Chloro-5-ethylpyrimidineHCID 68290215N-Cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide

Product 1

HCID 68290892N-Cyclopropyl-N-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-3-fluoro-4-oxazol-5-yl-benzamide

Procedure

The title compound is prepared from N-cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide and 2-chloro-5-ethyl-pyrimidine following a procedure analogous to that described in Example 19. LC (method 1): tR=1.16 min; Mass spectrum (ESI+): m/z=436 [M+H]+.

Sources & evidence

ORD record
ord-065cbdc2fd3a42a08be6a218ff307e59
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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