Potassium Cation → 4-Fluoro-1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine

HRID 688590Notes

Reaction equation

HRID 688590 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([F:26])[c:6]([C:8]2([c:19]3[cH:20][c:21]([CH3:25])[n:22][cH:23][cH:24]3)[N:9]=[C:10]([NH2:18])[c:11]3[c:12]([F:17])[cH:13][cH:14][cH:15][c:16]32)[cH:7]1.[C:36](=[O:37])([O-:38])[O-:39].[K+:40].[K+:41].[O:42]=[CH:43][N:44]([CH3:45])[CH3:46].[n:27]1[cH:28][n:29][cH:30][c:31]([B:33]([OH:34])[OH:35])[cH:32]1>>[c:2]1(-[c:31]2[cH:30][n:29][cH:28][n:27][cH:32]2)[cH:3][cH:4][c:5]([F:26])[c:6]([C:8]2([c:19]3[cH:20][c:21]([CH3:25])[n:22][cH:23][cH:24]3)[N:9]=[C:10]([NH2:18])[c:11]3[c:12]([F:17])[cH:13][cH:14][cH:15][c:16]32)[cH:7]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 2795193(Pyrimidin-5-yl)boronic acidHCID 585794991-(5-Bromo-2-fluorophenyl)-4-fluoro-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine

Product 1

HCID 462056374-Fluoro-1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine

Sources & evidence

ORD record
ord-422db1658e7b45b6a44dfd6d4c3a79ee
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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