Dichloromethane → 8-[4-[[5-[Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]benzoyl]-2-oxa-8-azaspiro[4.5]decan-1-one
Reaction equation
[Cl:48][CH2:49][Cl:50].[OH:1][CH:2]([CH:3]1[N:4]([C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[CH:5]([CH2:8][c:9]2[cH:10][cH:11][c:12]([C:15](=[O:16])[N:17]3[CH2:18][CH2:19][C:20]4([CH2:21][CH2:22][O:23][C:24]4=[O:25])[CH2:26][CH2:27]3)[cH:13][cH:14]2)[CH2:6][CH2:7]1)[c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1.[OH:41][C:42]([C:43]([F:44])([F:45])[F:46])=[O:47]>>[OH:1][CH:2]([CH:3]1[NH:4][CH:5]([CH2:8][c:9]2[cH:10][cH:11][c:12]([C:15](=[O:16])[N:17]3[CH2:18][CH2:19][C:20]4([CH2:21][CH2:22][O:23][C:24]4=[O:25])[CH2:26][CH2:27]3)[cH:13][cH:14]2)[CH2:6][CH2:7]1)[c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1Participants
4
Sources & evidence
- ORD record
- ord-e2daddea607340f391e157b15ff7ae20
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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