HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N-Cyclopropyl-N-[1-(6-cyclopropyl-pyridazin-3-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Chloro-6-cyclopropylpyridazine | HCID 52376167 | — |
| Reactant | N-Cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide | HCID 68289931 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-Cyclopropyl-N-[1-(6-cyclopropyl-pyridazin-3-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide | HCID 68290550 | — |
Reaction Steps
The title compound is prepared by reacting N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide and 3-chloro-6-cyclopropyl-pyridazine in the presence of K2CO3 in N-methylpyrrolidinone at 200° C. in a microwave vessel. LC (method 15): tR=1.26 min; Mass spectrum (ESI+): m/z=430 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822471B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-cc1c2f66c8b94835ab9d563e5234d80d |
| Source note | uspto-grants-2014_09 |