Potassium Carbonate → N-Cyclopropyl-N-[1-(6-cyclopropyl-pyridazin-3-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide

HRID 68867Notes

Reaction equation

HRID 68867 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.Cl[C:25]1[N:26]=[N:27][C:28]([CH:31]2[CH2:33][CH2:32]2)=[CH:29][CH:30]=1.C([O-])([O-])=O.[K+].[K+]>CN1CCCC1=O>[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([C:25]3[N:26]=[N:27][C:28]([CH:31]4[CH2:33][CH2:32]4)=[CH:29][CH:30]=3)[CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:7]=[CH:8][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:10][CH:11]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 523761673-Chloro-6-cyclopropylpyridazineHCID 68289931N-Cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide

Product 1

HCID 68290550N-Cyclopropyl-N-[1-(6-cyclopropyl-pyridazin-3-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound is prepared by reacting N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide and 3-chloro-6-cyclopropyl-pyridazine in the presence of K2CO3 in N-methylpyrrolidinone at 200° C. in a microwave vessel. LC (method 15): tR=1.26 min; Mass spectrum (ESI+): m/z=430 [M+H]+.

Workup

  1. customat 200° C.

Sources & evidence

ORD record
ord-cc1c2f66c8b94835ab9d563e5234d80d
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

Loading…