2-Bromo-5-cyclopropylpyrazine → N-Cyclopropyl-N-[1-(5-cyclopropyl-pyrazin-2-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide

HRID 68873Notes

Reaction equation

HRID 68873 reaction equation
Cl.[CH:2]1([N:5]([CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[C:6](=[O:18])[C:7]2[CH:12]=[CH:11][C:10]([C:13]3[O:17][CH:16]=[N:15][CH:14]=3)=[CH:9][CH:8]=2)[CH2:4][CH2:3]1.Br[C:26]1[CH:31]=[N:30][C:29]([CH:32]2[CH2:34][CH2:33]2)=[CH:28][N:27]=1>CN1CCCC1=O>[CH:2]1([N:5]([CH:19]2[CH2:24][CH2:23][N:22]([C:26]3[CH:31]=[N:30][C:29]([CH:32]4[CH2:34][CH2:33]4)=[CH:28][N:27]=3)[CH2:21][CH2:20]2)[C:6](=[O:18])[C:7]2[CH:8]=[CH:9][C:10]([C:13]3[O:17][CH:16]=[N:15][CH:14]=3)=[CH:11][CH:12]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 457876352-Bromo-5-cyclopropylpyrazineHCID 68289930N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride

Product 1

HCID 68290500N-Cyclopropyl-N-[1-(5-cyclopropyl-pyrazin-2-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride and 2-bromo-5-cyclopropyl-pyrazine following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 16): tR=0.46 min; Mass spectrum (ESI+): m/z=430 [M+H]+.

Sources & evidence

ORD record
ord-2160d1262d6b41659aed5579515d9096
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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