HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloropyrazine-2-carbonitrile → N-[1-(5-Cyano-pyrazin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloropyrazine-2-carbonitrile | HCID 12295728 | — |
| Reactant | N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride | HCID 68289930 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-[1-(5-Cyano-pyrazin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide | HCID 71293543 | — |
Reaction Steps
The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride and 5-chloro-pyrazine-2-carbonitrile following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 16): tR=0.46 min; Mass spectrum (ESI+): m/z=415 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822471B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-82a3b07be7af45ba913783b49ea1b960 |
| Source note | uspto-grants-2014_09 |