5-Chloropyrazine-2-carbonitrile → N-[1-(5-Cyano-pyrazin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide

HRID 68881Notes

Reaction equation

HRID 68881 reaction equation
Cl.[CH:2]1([N:5]([CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[C:6](=[O:18])[C:7]2[CH:12]=[CH:11][C:10]([C:13]3[O:17][CH:16]=[N:15][CH:14]=3)=[CH:9][CH:8]=2)[CH2:4][CH2:3]1.Cl[C:26]1[N:27]=[CH:28][C:29]([C:32]#[N:33])=[N:30][CH:31]=1>CN1CCCC1=O>[C:32]([C:29]1[N:30]=[CH:31][C:26]([N:22]2[CH2:23][CH2:24][CH:19]([N:5]([CH:2]3[CH2:4][CH2:3]3)[C:6](=[O:18])[C:7]3[CH:8]=[CH:9][C:10]([C:13]4[O:17][CH:16]=[N:15][CH:14]=4)=[CH:11][CH:12]=3)[CH2:20][CH2:21]2)=[N:27][CH:28]=1)#[N:33]

Participants

4

Reactant 2

HCID 122957285-Chloropyrazine-2-carbonitrileHCID 68289930N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride

Product 1

HCID 71293543N-[1-(5-Cyano-pyrazin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride and 5-chloro-pyrazine-2-carbonitrile following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 16): tR=0.46 min; Mass spectrum (ESI+): m/z=415 [M+H]+.

Sources & evidence

ORD record
ord-82a3b07be7af45ba913783b49ea1b960
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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