4-(5-Methyl-1H-1,2,4-triazol-1-yl)benzoic acid → N-Cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-4-(5-methyl-[1,2,4]triazol-1-yl)-benzamide

HRID 68893Notes

Reaction equation

HRID 68893 reaction equation
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[O:15][N:14]=[C:13]([CH:16]([CH3:18])[CH3:17])[N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[CH3:19][C:20]1[N:24]([C:25]2[CH:33]=[CH:32][C:28]([C:29](O)=[O:30])=[CH:27][CH:26]=2)[N:23]=[CH:22][N:21]=1>>[CH:1]1([N:4]([CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[O:15][N:14]=[C:13]([CH:16]([CH3:18])[CH3:17])[N:12]=3)[CH2:7][CH2:6]2)[C:29](=[O:30])[C:28]2[CH:27]=[CH:26][C:25]([N:24]3[C:20]([CH3:19])=[N:21][CH:22]=[N:23]3)=[CH:33][CH:32]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 682895874-(5-Methyl-1H-1,2,4-triazol-1-yl)benzoic acidHCID 68290028N-cyclopropyl-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-amine

Product 1

HCID 71293507N-Cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-4-(5-methyl-[1,2,4]triazol-1-yl)-benzamide

Procedure

The title compound is prepared from cyclopropyl-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amine and 4-(5-methyl-[1,2,4]triazol-1-yl)-benzoic acid following a procedure analogous to that described in Example 90. LC (method 19): tR=3.30 min; Mass spectrum (ESI+): m/z=436 [M+H]+.

Sources & evidence

ORD record
ord-431b0787257a4482bed1cc0051719a00
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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