4-(2-methyl-1H-imidazol-1-yl)benzoic acid → N-Cyclopropyl-N-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-4-(2-methyl-imidazol-1-yl)-benzamide

HRID 68897Notes

Reaction equation

HRID 68897 reaction equation
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[N:16]=[CH:15][C:14]([CH2:17][CH3:18])=[CH:13][N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[CH3:19][C:20]1[N:21]([C:25]2[CH:33]=[CH:32][C:28]([C:29](O)=[O:30])=[CH:27][CH:26]=2)[CH:22]=[CH:23][N:24]=1>>[CH:1]1([N:4]([CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[N:12]=[CH:13][C:14]([CH2:17][CH3:18])=[CH:15][N:16]=3)[CH2:7][CH2:6]2)[C:29](=[O:30])[C:28]2[CH:27]=[CH:26][C:25]([N:21]3[CH:22]=[CH:23][N:24]=[C:20]3[CH3:19])=[CH:33][CH:32]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 138159884-(2-methyl-1H-imidazol-1-yl)benzoic acidHCID 68289588N-cyclopropyl-1-(5-ethylpyrimidin-2-yl)piperidin-4-amine

Product 1

HCID 68290608N-Cyclopropyl-N-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-4-(2-methyl-imidazol-1-yl)-benzamide

Procedure

The title compound is prepared from cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amine and 4-(2-methyl-imidazol-1-yl)-benzoic acid following a procedure analogous to that described in Example 90. LC (method 19): tR=3.84 min; Mass spectrum (ESI+): m/z=431 [M+H]+.

Sources & evidence

ORD record
ord-c803a2d3f3b741d88d1f78a50f0235ba
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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