3-fluoro-4-(1H-1,2,4-triazol-1-yl)benzoic acid → N-Cyclopropyl-N-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-3-fluoro-4-[1,2,4]triazol-1-yl-benzamide

HRID 68900Notes

Reaction equation

HRID 68900 reaction equation
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[N:16]=[CH:15][C:14]([CH2:17][CH3:18])=[CH:13][N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[F:19][C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][C:28]=1[N:29]1[CH:33]=[N:32][CH:31]=[N:30]1)[C:23](O)=[O:24]>>[CH:1]1([N:4]([CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[N:12]=[CH:13][C:14]([CH2:17][CH3:18])=[CH:15][N:16]=3)[CH2:7][CH2:6]2)[C:23](=[O:24])[C:22]2[CH:26]=[CH:27][C:28]([N:29]3[CH:33]=[N:32][CH:31]=[N:30]3)=[C:20]([F:19])[CH:21]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 286045763-fluoro-4-(1H-1,2,4-triazol-1-yl)benzoic acidHCID 68289588N-cyclopropyl-1-(5-ethylpyrimidin-2-yl)piperidin-4-amine

Product 1

HCID 71293506N-Cyclopropyl-N-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-3-fluoro-4-[1,2,4]triazol-1-yl-benzamide

Procedure

The title compound is prepared from cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amine and 3-fluoro-4-[1,2,4]triazol-1-yl-benzoic acid following a procedure analogous to that described in Example 90. LC (method 19): tR=4.25 min; Mass spectrum (ESI+): m/z=436 [M+H]+.

Sources & evidence

ORD record
ord-1376594ff4c948e881b06040421ac55a
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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