HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-fluoro-4-(1H-1,2,4-triazol-1-yl)benzoic acid → N-Cyclopropyl-N-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-3-fluoro-4-[1,2,4]triazol-1-yl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-fluoro-4-(1H-1,2,4-triazol-1-yl)benzoic acid | HCID 28604576 | — |
| Reactant | N-cyclopropyl-1-(5-ethylpyrimidin-2-yl)piperidin-4-amine | HCID 68289588 | — |
| Product | N-Cyclopropyl-N-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-3-fluoro-4-[1,2,4]triazol-1-yl-benzamide | HCID 71293506 | — |
Reaction Steps
The title compound is prepared from cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amine and 3-fluoro-4-[1,2,4]triazol-1-yl-benzoic acid following a procedure analogous to that described in Example 90. LC (method 19): tR=4.25 min; Mass spectrum (ESI+): m/z=436 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822471B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-1376594ff4c948e881b06040421ac55a |
| Source note | uspto-grants-2014_09 |