4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)benzoic acid → N-[1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-(5-methyl-tetrazol-1-yl)-benzamide

HRID 68906Notes

Reaction equation

HRID 68906 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([NH:14][CH:15]3[CH2:17][CH2:16]3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[CH3:18][C:19]1[N:23]([C:24]2[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=2)[N:22]=[N:21][N:20]=1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([N:14]([CH:15]3[CH2:17][CH2:16]3)[C:28](=[O:29])[C:27]3[CH:31]=[CH:32][C:24]([N:23]4[C:19]([CH3:18])=[N:20][N:21]=[N:22]4)=[CH:25][CH:26]=3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 31552494-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)benzoic acidHCID 682895731-(5-chloropyrimidin-2-yl)-N-cyclopropylpiperidin-4-amine

Product 1

HCID 68290744N-[1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-(5-methyl-tetrazol-1-yl)-benzamide

Procedure

The title compound is prepared from [1-(5-chloro-pyrimidin-2-yl)-piperidin-4-yl]-cyclopropyl-amine and 4-(5-methyl-tetrazol-1-yl)-benzoic acid following a procedure analogous to that described in Example 107. LC (method 19): tR=4.02 min; Mass spectrum (ESI+): m/z=439 [M+H]+.

Sources & evidence

ORD record
ord-f529d28287d6460eae53928b1f69dc17
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

Loading…