反应详情

温度

65 °C

Sodium ethoxide (204 mg) was added to an ethanol solution (15 ml) of N-(2-amino-5-methoxyphenyl)-N-methylmalonamic acid ethyl ester (266 mg). The mixture was stirred at 65° C. for 2.5 hours. The reaction liquid was cooled to room temperature, and condensed under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane:methanol=1:0→10:1). The purified product was condensed to dryness under reduced pressure to give the title compound (176.3 mg) as a white powder.

1. customThe reaction liquid
2. temperaturewas cooled to room temperature
3. customcondensed under reduced pressure
4. customThe residue was purified by silica gel column chromatography (dichloromethane:methanol=1:0→10:1)
5. customcondensed to dryness under reduced pressure