Hydrochloric Acid → 1-[2-(4-Aminopiperidin-1-yl)ethyl]-6,8-difluoroquinoxalin-2(1H)-one

HRID 689563Notes

Reaction equation

HRID 689563 reaction equation
[C:1]([N:5]([C:2](=[O:3])[O-:4])[CH:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][n:17]2[c:18](=[O:29])[cH:19][n:20][c:21]3[cH:22][c:23]([F:28])[cH:24][c:25]([F:27])[c:26]23)[CH2:13][CH2:14]1)([CH3:6])([CH3:7])[CH3:8].[ClH:30].[NH2:31][CH:32]1[CH2:33][CH2:34][N:35]([CH2:36][CH2:37][n:38]2[c:39]3[c:40]([c:41]([F:42])[cH:43][c:44]([F:45])[cH:46]3)[n:47][cH:48][c:49]2=[O:50])[CH2:51][CH2:52]1.[O:53]1[CH2:54][CH2:55][O:56][CH2:57][CH2:58]1>>[NH2:5][CH:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][n:17]2[c:18](=[O:29])[cH:19][n:20][c:21]3[cH:22][c:23]([F:28])[cH:24][c:25]([F:27])[c:26]23)[CH2:13][CH2:14]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 667741441-[2-(4-aminopiperidin-1-yl)ethyl]-5,7-difluoroquinoxalin-2(1H)-oneHCID 178449656N-tert-butyl-N-[1-[2-(6,8-difluoro-2-oxoquinoxalin-1-yl)ethyl]piperidin-4-yl]carbamate

Product 1

HCID 667739801-[2-(4-Aminopiperidin-1-yl)ethyl]-6,8-difluoroquinoxalin-2(1H)-one

Sources & evidence

ORD record
ord-2cdcf54500964876b158905d87c46eb7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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