1-Butanol → alpha,alpha-Bis(4-fluorophenyl)-1-[3-(3-methylphenoxy)propyl]-4-piperidinemethanol

HRID 689567Notes

Reaction equation

HRID 689567 reaction equation
[CH2:43]([OH:44])[CH2:45][CH2:46][CH3:47].[CH3:48][CH:49]([OH:50])[CH3:51].[Cl:23][CH2:24][CH2:25][CH2:26][O:27][c:28]1[cH:29][c:30]([CH3:34])[cH:31][cH:32][cH:33]1.[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]([OH:9])([CH:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)[c:16]2[cH:17][cH:18][c:19]([F:22])[cH:20][cH:21]2)[cH:6][cH:7]1.[I-:42].[K+:41].[Na+:35].[Na+:36].[O-:37][C:38](=[O:39])[O-:40]>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]([OH:9])([CH:10]2[CH2:11][CH2:12][N:13]([CH2:24][CH2:25][CH2:26][O:27][c:28]3[cH:29][c:30]([CH3:34])[cH:31][cH:32][cH:33]3)[CH2:14][CH2:15]2)[c:16]2[cH:17][cH:18][c:19]([F:22])[cH:20][cH:21]2)[cH:6][cH:7]1

Participants

9

Reactant 8

HCID 2631-ButanolHCID 813Potassium CationHCID 923Sodium ion2×HCID 3776IsopropanolHCID 19660Carbonate IonHCID 30165Iodide IonHCID 11208889Bis(4-fluorophenyl)(piperidin-4-yl)methanolHCID 127603061-(3-Chloropropoxy)-3-methylbenzene

Product 1

HCID 23036447alpha,alpha-Bis(4-fluorophenyl)-1-[3-(3-methylphenoxy)propyl]-4-piperidinemethanol

Sources & evidence

ORD record
ord-226b24c7a5104f758aa6476a72c284ff
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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