Hydrogen chloride-ethyl acetate → HCID 70657289, compound

HRID 68967Notes

Reaction equation

HRID 68967 reaction equation
[ClH:1].CCOC(C)=O.[CH2:8]([N:10]1[C:16](=[O:17])[C:15]([CH3:19])([CH3:18])[C:14](=[O:20])[N:13]([CH3:21])[C:12]2[CH:22]=[C:23]([CH2:26][N:27]([CH2:41][C:42]3[C:43]([CH2:48][O:49][CH3:50])=[N:44][CH:45]=[CH:46][CH:47]=3)[CH2:28][CH2:29][N:30]3[CH:35]=[C:34]([CH3:36])[C:33]4[O:37][CH:38]=[CH:39][C:32]=4[C:31]3=[O:40])[CH:24]=[CH:25][C:11]1=2)[CH3:9]>C(OCC)(=O)C>[ClH:1].[ClH:1].[CH2:8]([N:10]1[C:16](=[O:17])[C:15]([CH3:19])([CH3:18])[C:14](=[O:20])[N:13]([CH3:21])[C:12]2[CH:22]=[C:23]([CH2:26][N:27]([CH2:41][C:42]3[C:43]([CH2:48][O:49][CH3:50])=[N:44][CH:45]=[CH:46][CH:47]=3)[CH2:28][CH2:29][N:30]3[CH:35]=[C:34]([CH3:36])[C:33]4[O:37][CH:38]=[CH:39][C:32]=4[C:31]3=[O:40])[CH:24]=[CH:25][C:11]1=2)[CH3:9]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 509916451-ethyl-7-({(2-methoxymethylpyridin-3-ylmethyl)-[2-(7-methyl-4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]amino}methyl)-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

Product 1

HCID 70657289HCID 70657289, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4 M HCl/AcOEt (90 μl) was added to an ethyl acetate solution (1 ml) of 1-ethyl-7-({(2-methoxymethylpyridin-3-ylmethyl)-[2-(7-methyl-4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]amino}methyl)-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione (26 mg) and stirred for 5 minutes at room temperature. The resulting precipitate was collected and washed with ether to give the title compound as a white powder (14 mg).

Workup

  1. customThe resulting precipitate was collected
  2. washwashed with ether

Sources & evidence

ORD record
ord-416deb5b9d2240c9b866e2628ecd178b
Source dataset
uspto-grants-2014_09
Patent number
US08822453B2

Reaction notes

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