HRID68967

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21866389

未命名化合物

结构：CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(CN(CCn3cc(C)c4occc4c3=O)Cc3cccnc3COC)ccc21

HCID50991645

未命名化合物

PRODUCTS

生成物

结构：CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(CN(CCn3cc(C)c4occc4c3=O)Cc3cccnc3COC)ccc21.Cl.Cl

HCID70657289

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

4 M HCl/AcOEt (90 μl) was added to an ethyl acetate solution (1 ml) of 1-ethyl-7-({(2-methoxymethylpyridin-3-ylmethyl)-[2-(7-methyl-4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]amino}methyl)-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione (26 mg) and stirred for 5 minutes at room temperature. The resulting precipitate was collected and washed with ether to give the title compound as a white powder (14 mg).

WORKUP

后处理

customThe resulting precipitate was collected
washwashed with ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-416deb5b9d2240c9b866e2628ecd178b
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08822453B2
来源说明: uspto-grants-2014_09

反应 SMILES

[ClH:1].CCOC(C)=O.[CH2:8]([N:10]1[C:16](=[O:17])[C:15]([CH3:19])([CH3:18])[C:14](=[O:20])[N:13]([CH3:21])[C:12]2[CH:22]=[C:23]([CH2:26][N:27]([CH2:41][C:42]3[C:43]([CH2:48][O:49][CH3:50])=[N:44][CH:45]=[CH:46][CH:47]=3)[CH2:28][CH2:29][N:30]3[CH:35]=[C:34]([CH3:36])[C:33]4[O:37][CH:38]=[CH:39][C:32]=4[C:31]3=[O:40])[CH:24]=[CH:25][C:11]1=2)[CH3:9]>C(OCC)(=O)C>[ClH:1].[ClH:1].[CH2:8]([N:10]1[C:16](=[O:17])[C:15]([CH3:19])([CH3:18])[C:14](=[O:20])[N:13]([CH3:21])[C:12]2[CH:22]=[C:23]([CH2:26][N:27]([CH2:41][C:42]3[C:43]([CH2:48][O:49][CH3:50])=[N:44][CH:45]=[CH:46][CH:47]=3)[CH2:28][CH2:29][N:30]3[CH:35]=[C:34]([CH3:36])[C:33]4[O:37][CH:38]=[CH:39][C:32]=4[C:31]3=[O:40])[CH:24]=[CH:25][C:11]1=2)[CH3:9]