Ethanol → HCID 66960064, compound

HRID 69014Notes

Reaction equation

HRID 69014 reaction equation
C(O)C.[ClH:4].C(O)C.[CH3:8][N:9]1[C:18]2[C:13](=[CH:14][C:15]([O:19][CH2:20][CH2:21][N:22]([CH2:30][CH2:31][C:32]3[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=3)[CH2:23][C:24]3[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=3)=[CH:16][CH:17]=2)[CH:12]=[CH:11][C:10]1=[O:38]>C(OCC)(=O)C>[ClH:4].[ClH:4].[ClH:4].[CH3:8][N:9]1[C:18]2[C:13](=[CH:14][C:15]([O:19][CH2:20][CH2:21][N:22]([CH2:30][CH2:31][C:32]3[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=3)[CH2:23][C:24]3[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=3)=[CH:16][CH:17]=2)[CH:12]=[CH:11][C:10]1=[O:38]

Participants

5

Reactant 3

HCID 702EthanolHCID 21887872Ethanol hydrochlorideHCID 66960065HCID 66960065, compound

Product 1

HCID 66960064HCID 66960064, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 1N-hydrogen chloride ethanol solution (1.7 ml) was added to an ethanol solution (10 ml) of 1-Methyl-6-{2-[(2-pyridin-3-ylethyl)pyridin-3-ylmethylamino]ethoxy}-1H-quinolin-2-one (195 mg), which was stirred at room temperature. The reaction mixture was condensed under reduced pressure and ethyl acetate was added to the residue. The precipitated insoluble matter was separated, washed with ethyl acetate, and dried to give the title compound (199 mg) as a pale yellow powder.

Workup

  1. additionwas added to the residue
  2. customThe precipitated insoluble matter was separated
  3. washwashed with ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-d7363c081c3a4bdfa123ba76ebcdd348
Source dataset
uspto-grants-2014_09
Patent number
US08822453B2

Reaction notes

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