1-(3-Chloromethyl-4-methyl-pyridin-2-ylmethyl)-3-trifluoromethyl-1H-pyridin-2-one → 1-(4-Methyl-3-{2-methyl-4-[4-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-quinolin-8-yloxymethyl}-pyridin-2-ylmethyl)-3-trifluoromethyl-1H-pyridin-2-one
Reaction equation
[CH3:1][c:2]1[n:3][c:4]2[c:5]([OH:24])[cH:6][cH:7][cH:8][c:9]2[c:10](-[c:12]2[n:13][n:14]([CH:18]3[O:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[cH:15][c:16]2[CH3:17])[cH:11]1.[Cl:25][CH2:26][c:27]1[c:28]([CH2:34][n:35]2[c:36](=[O:45])[c:37]([C:41]([F:42])([F:43])[F:44])[cH:38][cH:39][cH:40]2)[n:29][cH:30][cH:31][c:32]1[CH3:33].[Cl:46][c:47]1[cH:48][n:49][cH:50][c:51]([Cl:52])[c:53]1[CH2:54][O:55][c:56]1[cH:57][cH:58][cH:59][c:60]2[c:61]1[n:62][c:63]([CH3:64])[cH:65][c:66]2-[n:67]1[cH:68][cH:69][n:70][cH:71]1>>[CH3:1][c:2]1[n:3][c:4]2[c:5]([O:24][CH2:26][c:27]3[c:28]([CH2:34][n:35]4[c:36](=[O:45])[c:37]([C:41]([F:42])([F:43])[F:44])[cH:38][cH:39][cH:40]4)[n:29][cH:30][cH:31][c:32]3[CH3:33])[cH:6][cH:7][cH:8][c:9]2[c:10](-[c:12]2[n:13][n:14]([CH:18]3[O:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[cH:15][c:16]2[CH3:17])[cH:11]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-d7269f3e7c074b13925a3ec84b545f1d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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