反应详情

3N-Hydrochloric acid (5 ml) was added to a ethanol solution (5 ml) of N-[3-(1-Methyl-2-oxo-1,2-dihydroquinolin-6-yloxy)propyl]-N-(pyridin-3-ylmethyl)benzamide (250.1 mg), and stirred for 60 hours while heated under reflux. The reaction mixture was cooled to room temperature. Water was added thereto, washed with ethyl acetate. A saturated sodium hydrogencarbonate aqueous solution was added to the aqueous layer, followed by extraction using dichloromethane. The organic layer was dried with anhydrous sodium sulfate, and condensed under reduced pressure to give the title compound (168 mg) as a colorless oil.

1. temperaturewhile heated
2. temperatureunder reflux
3. washwashed with ethyl acetate
4. additionA saturated sodium hydrogencarbonate aqueous solution was added to the aqueous layer
5. extractionfollowed by extraction
6. dry with materialThe organic layer was dried with anhydrous sodium sulfate, and condensed under reduced pressure