Dichloromethane → 4,6-Bis(4-fluorophenyl)-2-(4-piperidyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridine

HRID 690318Notes

Reaction equation

HRID 690318 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([n:14]2[n:15][c:16]3[n:17][c:18](-[c:36]4[cH:37][cH:38][c:39]([F:42])[cH:40][cH:41]4)[c:19](-[c:30]4[cH:31][cH:32][n:33][cH:34][cH:35]4)[c:20](-[c:23]4[cH:24][cH:25][c:26]([F:29])[cH:27][cH:28]4)[c:21]3[cH:22]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:50][CH2:51][Cl:52].[OH:43][C:44]([C:45]([F:46])([F:47])[F:48])=[O:49]>>[NH:8]1[CH2:9][CH2:10][CH:11]([n:14]2[n:15][c:16]3[n:17][c:18](-[c:36]4[cH:37][cH:38][c:39]([F:42])[cH:40][cH:41]4)[c:19](-[c:30]4[cH:31][cH:32][n:33][cH:34][cH:35]4)[c:20](-[c:23]4[cH:24][cH:25][c:26]([F:29])[cH:27][cH:28]4)[c:21]3[cH:22]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 684430892-[1-(Tert-butoxycarbonyl)piperidin-4-yl]-4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridine

Product 1

HCID 670147574,6-Bis(4-fluorophenyl)-2-(4-piperidyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridine

Sources & evidence

ORD record
ord-f4c87107e90a48b38cd0d03d5087748b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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