Dichloromethane → 1,1-Dioxo-5-[2-phenylmethoxy-4-(2-piperidin-2-ylethenyl)phenyl]-2-(2-trimethylsilylethyl)-1,2,5-thiadiazolidin-3-one

HRID 690359Notes

Reaction equation

HRID 690359 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH:9]([CH:14]=[CH:15][c:16]2[cH:17][c:18]([O:36][CH2:37][c:38]3[cH:39][cH:40][cH:41][cH:42][cH:43]3)[c:19]([N:22]3[S:23](=[O:34])(=[O:35])[N:24]([CH2:28][CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33])[C:25](=[O:27])[CH2:26]3)[cH:20][cH:21]2)[CH2:10][CH2:11][CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH2:51]([Cl:52])[Cl:53].[F:44][C:45]([F:46])([F:47])[C:48]([OH:49])=[O:50]>>[NH:8]1[CH:9]([CH:14]=[CH:15][c:16]2[cH:17][c:18]([O:36][CH2:37][c:38]3[cH:39][cH:40][cH:41][cH:42][cH:43]3)[c:19]([N:22]3[S:23](=[O:34])(=[O:35])[N:24]([CH2:28][CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33])[C:25](=[O:27])[CH2:26]3)[cH:20][cH:21]2)[CH2:10][CH2:11][CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 68838477Tert-butyl 2-[2-[3-phenylmethoxy-4-[1,1,4-trioxo-5-(2-trimethylsilylethyl)-1,2,5-thiadiazolidin-2-yl]phenyl]ethenyl]piperidine-1-carboxylate

Product 1

HCID 688427251,1-Dioxo-5-[2-phenylmethoxy-4-(2-piperidin-2-ylethenyl)phenyl]-2-(2-trimethylsilylethyl)-1,2,5-thiadiazolidin-3-one

Sources & evidence

ORD record
ord-664404d81d3d4449a6d792d827ba836d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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