Methanol → [4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-phenyl]-methanol

HRID 690427Notes

Reaction equation

[BH4-:1].[CH2:21]([Cl:22])[Cl:23].[CH3:29][OH:30].[Na+:2].[O:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1.[O:3]1[CH2:4][CH2:5][O:6][C:7]12[CH2:8][CH2:9][N:10]([c:13]1[cH:14][cH:15][c:16]([CH:17]=[O:18])[cH:19][cH:20]1)[CH2:11][CH2:12]2>>[O:3]1[CH2:4][CH2:5][O:6][C:7]12[CH2:8][CH2:9][N:10]([c:13]1[cH:14][cH:15][c:16]([CH2:17][OH:18])[cH:19][cH:20]1)[CH2:11][CH2:12]2

Participants

Reactant 6

HCID 887Methanol

HCID 923Sodium ion

HCID 6344Dichloromethane

HCID 8028Tetrahydrofuran

HCID 28123Borohydride

HCID 27643354-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)benzaldehyde

Product 1

HCID 10586716[4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-phenyl]-methanol

Sources & evidence

ORD record: ord-edbdc075c5184c6c915c1f7a8c05dd43
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…