Dimethylformamide → 1-(pyridin-3-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one

HRID 69046Notes

Reaction equation

HRID 69046 reaction equation
CN([CH:4]=[O:5])C.[N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][C:13]2[C:14]([NH2:19])=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:7]=1>O>[N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N:12]2[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[NH:19][C:4]2=[O:5])[CH:7]=1

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 22736684N-(3-pyridyl)-o-phenylenediamine

Product 1

HCID 200892131-(pyridin-3-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N,N′-Carbonyldiimidazole (0.57 g) was added to a DMF solution (5 ml) of N-pyridine-3-ylbenzene-1,2-diamine (0.5 g). The mixture was stirred at room temperature for 1.5 hours. Water was added to the reaction mixture and the precipitated insoluble matter was separated, washed with water, and dried to give the title compound (0.5 g) as a pale whitish purple powder.

Workup

  1. customthe precipitated insoluble matter was separated
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-4cfc5cae69bb47789007e044dc545de1
Source dataset
uspto-grants-2014_09
Patent number
US08822453B2

Reaction notes

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