反应详情

Methane sulfonyl chloride (0.24 ml) was added to a dichloromethane solution (10 ml) of 5-(3-hydroxypropyl)-2-methyl-5H-furo[3,2-c]pyridine-4-one (0.28 g) and triethylamine (0.45 ml). The mixture was stirred at room temperature for two days. The reaction liquid was condensed under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:4→1:1). The purified product was condensed to dryness under reduced pressure to give the title compound (0.16 g) as a white amorphous solid.

1. customThe reaction liquid
2. customcondensed under reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:4→1:1)
4. customcondensed to dryness under reduced pressure