HRID69062

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6395

Methanesulfonic acid

CH4O3S

结构：CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCn3cc(-c4ccc(OC)nc4)c(=O)c4ccccc43)ccc21

HCID70656463

未命名化合物

PRODUCTS

生成物

结构：CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCn3cc(-c4ccc(OC)nc4)c(=O)c4ccccc43)ccc21.CS(=O)(=O)O

HCID86670487

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID22055037

未命名化合物

PROCEDURE

实验过程

Methanesulfonic acid (0.024 ml) was added to an ethyl acetate/isopropyl alcohol solution (1:1, 8 ml) of 1-ethyl-7-{3-[3-(6-methoxypyridin-3-yl)-4-oxo-4H-quinoline-1-yl]propoxy}-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione (0.2 g) at 0° C., which was stirred at the same temperature for 2 hours. The precipitated insoluble matter was separated, washed with isopropyl alcohol, and dried to give the title compound (0.19 g) as a white powder.

WORKUP

后处理

customThe precipitated insoluble matter was separated
washwashed with isopropyl alcohol
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a60fb4d16d844c2c944e5180c27bd9e0
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08822453B2
来源说明: uspto-grants-2014_09

反应 SMILES

[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH2:6]([N:8]1[C:14](=[O:15])[C:13]([CH3:17])([CH3:16])[C:12](=[O:18])[N:11]([CH3:19])[C:10]2[CH:20]=[C:21]([O:24][CH2:25][CH2:26][CH2:27][N:28]3[C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[C:31](=[O:38])[C:30]([C:39]4[CH:40]=[N:41][C:42]([O:45][CH3:46])=[CH:43][CH:44]=4)=[CH:29]3)[CH:22]=[CH:23][C:9]1=2)[CH3:7]>C(OCC)(=O)C.C(O)(C)C>[S:2]([OH:5])(=[O:4])(=[O:3])[CH3:1].[CH2:6]([N:8]1[C:14](=[O:15])[C:13]([CH3:17])([CH3:16])[C:12](=[O:18])[N:11]([CH3:19])[C:10]2[CH:20]=[C:21]([O:24][CH2:25][CH2:26][CH2:27][N:28]3[C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[C:31](=[O:38])[C:30]([C:39]4[CH:40]=[N:41][C:42]([O:45][CH3:46])=[CH:43][CH:44]=4)=[CH:29]3)[CH:22]=[CH:23][C:9]1=2)[CH3:7]