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HRID691

反应详情

EQUATION

反应方程式

HRID 691 的结构方程式

REACTANTS

反应物

2
结构：CS(=O)(=O)c1ccc(Br)cc1
HCID77014

1-Bromo-4-(methylsulphonyl)benzene

C7H7BrO2S

结构：C[C@@H]1CNCCN1C(=O)OC(C)(C)C
HCID10262201

tert-Butyl (2R)-2-methylpiperazine-1-carboxylate

C10H20N2O2

PRODUCTS

生成物

1
结构：C[C@@H]1CN(c2ccc(S(C)(=O)=O)cc2)CCN1C(=O)OC(C)(C)C
HCID133499578

未命名化合物

收率 0%

AUXILIARIES

试剂、催化剂与溶剂

4
结构：CC(C)(C)[O-].[K+]
试剂HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

结构：CC(C)(C)P(C(C)(C)C)C(C)(C)C
催化剂HCID83681

Tris(1,1-dimethylethyl)phosphine

C12H27P

结构：CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C.[Pd]
催化剂HCID2734558

Bis(tri-tert-butylphosphine)palladium(0)

C24H54P2Pd

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

13-May-09 10:32:28 +0100 1-bromo-4-(methylsulfonyl)benzene (515 mg, 2.13 mmol), (R)-tert-butyl 2-methylpiperazine-1-carboxylate (426 mg, 2.13 mmol) and BIS(TRI-T- BUTYLPHOSPHINE)PALLADIUM(0) (54.3 mg, 0.11 mmol) and potassium 2-methylpropan-2-olate (352 mg, 2.98 mmol) were suspended in dioxane (10 mL) and heated to 90°C for 3 hours. LC-MS shows starting material. Reaction abandoned.