反应详情

温度

90 °C

Under a nitrogen atmosphere, a mixture of 3.62 g of 1-(4-bromo-2-nitrophenyl)ethanone and 5.3 g of (dimethoxymethyl)dimethylamine was stirred at 90° C. for 4 hours. The reaction mixture was cooled to room temperature and the precipitated solid was collected by filtration. The obtained solid was washed with diisopropyl ether and dried under reduced pressure to obtain 3.93 g of (2E)-1-(4-bromo-2-nitrophenyl)-3-(dimethylamino)prop-2-en-1-one.

1. temperatureThe reaction mixture was cooled to room temperature
2. filtrationthe precipitated solid was collected by filtration
3. washThe obtained solid was washed with diisopropyl ether
4. customdried under reduced pressure