反应详情

温度

120 °C

Under a nitrogen atmosphere, 6.33 g of N-(2-acetyl-4-bromo-5-methylphenyl)acetamide was added to a mixture of 3.3 g of (dimethoxymethyl)dimethylamine and 19 mL of toluene, followed by stirring at 120° C. for 16 hours. The mixture was cooled to room temperature, concentrated, and diisopropyl ether was added thereto and triturated. The powder was collected by filtration, washed with diisopropyl ether, and then dried under reduced pressure to obtain 6.92 g of N-{4-bromo-2-[(2E)-3-(dimethylamino)prop-2-enoyl]-5-methylphenyl}acetamide.

1. temperatureThe mixture was cooled to room temperature
2. concentrationconcentrated
3. additiondiisopropyl ether was added
4. customtriturated
5. filtrationThe powder was collected by filtration
6. washwashed with diisopropyl ether
7. customdried under reduced pressure