1,4-Dioxane hydrochloride → HCID 86694323, compound

HRID 69118Notes

Reaction equation

HRID 69118 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[CH:2]=1.[ClH:23].O1CCOCC1>CO>[ClH:23].[ClH:23].[ClH:23].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:2]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86694324HCID 86694324, compound

Product 1

HCID 86694323HCID 86694323, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 420 mg of tert-butyl 4-[3-(pyridin-3-yl)propyl]piperazine-1-carboxylate in 6 mL of methanol was added 2 mL of a 4 M hydrogen chloride-dioxane solution, followed by stirring at room temperature for 16 hours. The solvent was evaporated under reduced pressure to obtain 395 mg of 1-[3-(pyridin-3-yl)propyl]piperazine trihydrochloride.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9210a322557b4b419cafdd1dcfd5ad8d
Source dataset
uspto-grants-2014_09
Patent number
US08822448B2

Reaction notes

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