Tetrahydrofuran → 1-[cis-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-3-(2,6-dichloro-4-hydroxy-benzyl)-pyrrolidin-2-one
Reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]([Cl:37])[c:12]([CH2:13][CH:14]2[C:15](=[O:33])[N:16]([CH:19]3[CH2:20][CH2:21][CH:22]([O:25][Si:26]([CH3:27])([CH3:28])[C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:23][CH2:24]3)[CH2:17][CH2:18]2)[c:34]([Cl:36])[cH:35]1.[Cl:38][c:39]1[cH:40][c:41]([O:42][CH2:43][c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[cH:50][c:51]([Cl:52])[c:53]1[CH:54]=[O:55].[O:56]1[CH2:57][CH2:58][CH2:59][CH2:60]1>>[OH:8][c:9]1[cH:10][c:11]([Cl:37])[c:12]([CH2:13][CH:14]2[C:15](=[O:33])[N:16]([CH:19]3[CH2:20][CH2:21][CH:22]([O:25][Si:26]([CH3:27])([CH3:28])[C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:23][CH2:24]3)[CH2:17][CH2:18]2)[c:34]([Cl:36])[cH:35]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-fe1a49c020954bbab23aed9c1f6c9691
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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