Aniline → HCID 57917317, compound

Participants

Role	Name	HCID	Charge
Reactant	Aniline	HCID 6115	—
Reactant	3-Chloroaniline	HCID 7932	—
Reactant	(3-Chloro-phenyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine	HCID 57917421	—
Product	HCID 57917317	HCID 57917317	—

Reaction Steps

The title compound was prepared in analogy to the compound of Example 121 using aniline as starting material instead of 3-chloroaniline and with a preparative LCMS purification instead of a flash chromatography (tR 4.30 min (conditions 4), MH+=352.3, 1H-NMR in DMSO-d6: 8.91 (m, 1H); 8.36 (m, 1H); 8.17 (d, 1H); 8.08 (s, 1H); 8.03 (d, 1H); 7.96 (m, 1H); 7.79 (m, 1H); 7.58 (dd, 1H); 7.50 (m, 2H); 7.35 (d, 1H); 7.25 (t, 2H); 7.01 (t, 1H); 4.59 (s, 2H)).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08822468B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-83372ea55fab41b5b6b07391a57a134b
Source note	uspto-grants-2014_09