反应详情

温度

0 °C

(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-quinolin-6-yl-methanone (Stage 1.2, 500 mg, 1.62 mmol) was dissolved in anhydrous THF (10 mL) and cooled down to 0° C. Methylmagnesium bromide in toluene/THF (1.4 M, 1.27 mL) was slowly added and the RM was then warmed up to rt and stirred for 4 h. Water (2 mL) was added and the precipitate formed was filtered off. The filtrate was concentrated to give the title compound as a brown solid (tR 0.50 min (conditions 2), (MH+=325).

1. temperaturethe RM was then warmed up to rt
2. customthe precipitate formed
3. filtrationwas filtered off
4. concentrationThe filtrate was concentrated