反应详情

TBAF (1 M, 200 uL) was added to (rac)-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-5-yl]-methanol (Stage 162.2, 42 mg, 0.088 mmol) dissolved in THF (3 ml). The reaction mixture was heated at reflux for 1 h. After evaporation of the solvent, the residue was taken into EtOAc and washed with saturated aqueous sodium carbonate. The aqueous phase was again extracted with EtOAc (3×) and combined organic layers were dried on Na2SO4. After evaporation of the solvent, the title compound was obtained as an oil (tR 0.01 min (conditions 2), MH+=346).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 1 h
3. customAfter evaporation of the solvent
4. washwashed with saturated aqueous sodium carbonate
5. extractionThe aqueous phase was again extracted with EtOAc (3×)
6. customwere dried on Na2SO4
7. customAfter evaporation of the solvent