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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 692447Generated: October 31, 2026

Tetrahydrofuran → 3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-3-hydroxy-1-(4-methyl-5-trimethylsilanylethynyl-thiophen-2-yl)-butan-1-one

https://huagongshe.com/reaction/692447

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
Reactanttert-Butyl methyl etherHCID 15413—
ReactantLithium ionHCID 28486—
ReactantHydrideHCID 166653—
Reactant1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethan-1-oneHCID 2758231—
Reactant1-(4-Methyl-5-trimethylsilanylethynyl-thiophen-2-yl)-ethanoneHCID 67430140—
Product3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-3-hydroxy-1-(4-methyl-5-trimethylsilanylethynyl-thiophen-2-yl)-butan-1-oneHCID 67429131—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (3/10)
ORD IDord-ad15ab9dddf84b2aadbcd8dda87bd804
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (3/10)