Tetrahydrofuran → 3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-3-hydroxy-1-(4-methyl-5-trimethylsilanylethynyl-thiophen-2-yl)-butan-1-one

HRID 692447Notes

Reaction equation

HRID 692447 reaction equation
[C:32]([O:33][CH3:34])([CH3:35])([CH3:36])[CH3:37].[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH3:17][c:18]1[cH:19][c:20]([C:29]([CH3:30])=[O:31])[s:21][c:22]1[C:23]#[C:24][Si:25]([CH3:26])([CH3:27])[CH3:28].[Cl:3][c:4]1[cH:5][c:6]([C:11]([C:12]([F:13])([F:14])[F:15])=[O:16])[cH:7][c:8]([Cl:10])[cH:9]1.[H-:1].[Li+:2]>>[Cl:3][c:4]1[cH:5][c:6]([C:11]([C:12]([F:13])([F:14])[F:15])([OH:16])[CH2:30][C:29]([c:20]2[cH:19][c:18]([CH3:17])[c:22]([C:23]#[C:24][Si:25]([CH3:26])([CH3:27])[CH3:28])[s:21]2)=[O:31])[cH:7][c:8]([Cl:10])[cH:9]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 15413tert-Butyl methyl etherHCID 28486Lithium ionHCID 166653HydrideHCID 27582311-(3,5-Dichlorophenyl)-2,2,2-trifluoroethan-1-oneHCID 674301401-(4-Methyl-5-trimethylsilanylethynyl-thiophen-2-yl)-ethanone

Product 1

HCID 674291313-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-3-hydroxy-1-(4-methyl-5-trimethylsilanylethynyl-thiophen-2-yl)-butan-1-one

Sources & evidence

ORD record
ord-ad15ab9dddf84b2aadbcd8dda87bd804
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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