Methylamine → Methyl-{2-[4-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrazol-1-yl]-ethyl}-amine

Participants

Role	Name	HCID	Charge
Reactant	Methylamine	HCID 6329	—
Reactant	6-{6-[1-(2-Pyrrolidin-1-yl-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-quinoline	HCID 57917308	—
Solvent	Methanol	HCID 887	—
Product	Methyl-{2-[4-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrazol-1-yl]-ethyl}-amine	HCID 57917321	—

Reaction Steps

The title compound was prepared in analogy to the compound of Example 236 using a 2 M solution of methylamine in MeOH instead of pyrrolidine (tR 2.61 min (conditions 3), MH+=384.3, 1H-NMR in DMSO-d6: 8.82 (m, 1H); 8.56 (s, 1H); 8.32 (m, 1H); 8.19 (s, 2H); 8.11 (d, 1H); 7.94 (m, 2H); 7.78 (m, 1H); 7.66 (s, 1H); 7.54 (d, 1H); 7.48 (dd, 1H); 4.53 (m, 4H); 3.40 (t, 2H); 2.55 (s, 3H)).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08822468B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-d4c226302c07451ba5b5d81cddd385f4
Source note	uspto-grants-2014_09