Tetrahydrofuran → N-{5-[2-Cyclobutyl-5-(2-{[1-(methylsulfonyl)-4-piperidinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

HRID 692946Notes

Reaction equation

HRID 692946 reaction equation
[CH2:47]1[O:48][CH2:49][CH2:50][CH2:51]1.[CH3:36][S:37](=[O:38])(=[O:39])[N:40]1[CH2:41][CH2:42][CH:43]([NH2:46])[CH2:44][CH2:45]1.[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:17]3[cH:18][cH:19][c:20]([F:35])[c:21]([NH:23][S:24](=[O:25])(=[O:26])[c:27]4[c:28]([F:34])[cH:29][cH:30][c:31]([F:33])[cH:32]4)[cH:22]3)[n:10][c:11]([CH:13]3[CH2:14][CH2:15][CH2:16]3)[s:12]2)[n:7]1>>[c:2]1([NH:46][CH:43]2[CH2:42][CH2:41][N:40]([S:37]([CH3:36])(=[O:38])=[O:39])[CH2:45][CH2:44]2)[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:17]3[cH:18][cH:19][c:20]([F:35])[c:21]([NH:23][S:24](=[O:25])(=[O:26])[c:27]4[c:28]([F:34])[cH:29][cH:30][c:31]([F:33])[cH:32]4)[cH:22]3)[n:10][c:11]([CH:13]3[CH2:14][CH2:15][CH2:16]3)[s:12]2)[n:7]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 113558261-(Methanesulfonyl)piperidin-4-amineHCID 57989980N-{5-[5-(2-Chloro-4-pyrimidinyl)-2-cyclobutyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Product 1

HCID 57989712N-{5-[2-Cyclobutyl-5-(2-{[1-(methylsulfonyl)-4-piperidinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-fc747e1d04af4bc3aa9d97e476814e9b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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