Dichloromethane → tert-butyl-2-bromo-1-(2-{(2-bromo-5-chlorobenzyl)[2-(dimethylamino)ethyl]amino}-2-oxoethyl)-3-cyclohexyl-1H-indole-6-carboxylate

HRID 693032Notes

Reaction equation

HRID 693032 reaction equation
[Br:1][c:2]1[n:3]([CH2:24][C:25](=[O:26])[OH:27])[c:4]2[cH:5][c:6]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[cH:7][cH:8][c:9]2[c:10]1[CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1.[Br:28][c:29]1[c:30]([CH2:31][NH:32][CH2:33][CH2:34][N:35]([CH3:36])[CH3:37])[cH:38][c:39]([Cl:42])[cH:40][cH:41]1.[CH:43]([N:44]([CH2:45][CH3:46])[CH:47]([CH3:48])[CH3:49])([CH3:50])[CH3:51].[Cl:76][CH2:77][Cl:78].[P-:52]([F:53])([F:54])([F:55])([F:56])([F:57])[F:58].[n:59]1([O:60][C:61]([N:62]([CH3:63])[CH3:64])=[N+:65]([CH3:66])[CH3:67])[c:68]2[n:69][cH:70][cH:71][cH:72][c:73]2[n:74][n:75]1>>[Br:1][c:2]1[n:3]([CH2:24][C:25](=[O:26])[N:32]([CH2:31][c:30]2[c:29]([Br:28])[cH:41][cH:40][c:39]([Cl:42])[cH:38]2)[CH2:33][CH2:34][N:35]([CH3:36])[CH3:37])[c:4]2[cH:5][c:6]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[cH:7][cH:8][c:9]2[c:10]1[CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 66160827N'-(2-bromo-5-chlorobenzyl)-N,N-dimethylethane-1,2-diamineHCID 68509336[2-bromo-6-(tert-butoxycarbonyl)-3-cyclohexyl-1H-indol-1-yl]acetic acid

Product 1

HCID 68507168tert-butyl-2-bromo-1-(2-{(2-bromo-5-chlorobenzyl)[2-(dimethylamino)ethyl]amino}-2-oxoethyl)-3-cyclohexyl-1H-indole-6-carboxylate

Sources & evidence

ORD record
ord-1b4472f0d4b4492b850046845293ed14
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…