Dichloromethane → Methyl 6-[4-({[5-cyclopropyl-3-(3,5-dichloro-4-pyridinyl)-4-isoxazolyl]methyl}oxy)phenyl]-2-quinolinecarboxylate

HRID 693406Notes

Reaction equation

HRID 693406 reaction equation
[CH:41]1([c:44]2[c:45]([CH2:57][OH:58])[c:46](-[c:49]3[c:50]([Cl:56])[cH:51][n:52][cH:53][c:54]3[Cl:55])[n:47][o:48]2)[CH2:42][CH2:43]1.[Cl:73][CH2:74][Cl:75].[O:59]=[C:60]([O:61][CH:62]([CH3:63])[CH3:64])[N:65]=[N:66][C:67]([O:68][CH:69]([CH3:70])[CH3:71])=[O:72].[OH:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][c:10]3[cH:11][cH:12][c:13]([C:18](=[O:19])[O:20][CH3:21])[n:14][c:15]3[cH:16][cH:17]2)[cH:6][cH:7]1.[c:22]1([P:23]([c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[cH:36][cH:37][cH:38][cH:39][cH:40]1>>[O:1]([c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][c:10]3[cH:11][cH:12][c:13]([C:18](=[O:19])[O:20][CH3:21])[n:14][c:15]3[cH:16][cH:17]2)[cH:6][cH:7]1)[CH2:57][c:45]1[c:44]([CH:41]2[CH2:42][CH2:43]2)[o:48][n:47][c:46]1-[c:49]1[c:50]([Cl:56])[cH:51][n:52][cH:53][c:54]1[Cl:55]

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 593215255-Cyclopropyl-3-(3,5-dichloro-4-pyridyl)isoxazole-4-methanolHCID 59321540Methyl 6-(4-hydroxyphenyl)-2-quinolinecarboxylate

Product 1

HCID 59321467Methyl 6-[4-({[5-cyclopropyl-3-(3,5-dichloro-4-pyridinyl)-4-isoxazolyl]methyl}oxy)phenyl]-2-quinolinecarboxylate

Sources & evidence

ORD record
ord-6c4210b308104fcc866a2f5af4ac2e37
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…