反应详情

温度

150 °C

A mixture of 5-chloro-6-nitroisoindoline-1,3-dione (28.0 g, 0.123 mol) and urea (73.8 g, 1.23 mol) was stirred and heated to 150° C. under argon for 6 h. After cooled to rt, the solid was suspended in hot water (100 mL, 80° C.), filtered, washed with hot water (3×50 mL) and dried under vacuum to give a yellow solid product, 23.56 g, 92.5% yield.

1. temperatureAfter cooled to rt
2. filtrationfiltered
3. washwashed with hot water (3×50 mL)
4. customdried under vacuum
5. customto give a yellow solid product, 23.56 g, 92.5% yield