反应详情

To a solution of (R)-2-(4-chloro-2-methoxypyridin-3-yl)-6-(2,3-dihydroxypropyl)imidazo[4,5-f]isoindole-5,7(1H,6H)-dione (380 mg, 0.95 mmol) in 50 mL of dioxane was added 1 mL of conc. HCl. The mixture was heated to reflux and maintained for 3 h. The solvent was removed by rotary evaporation and the solid residue was triturated with n-butanol three times to give a white solid which was used directly in the next step. APCI MS: m/z 389.0 (M+1).

1. temperatureThe mixture was heated
2. temperatureto reflux
3. temperaturemaintained for 3 h
4. customThe solvent was removed by rotary evaporation
5. customthe solid residue was triturated with n-butanol three times
6. customto give a white solid which