Tetrahydrofuran → N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N'-(2-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl)urea

HRID 693858Notes

Reaction equation

HRID 693858 reaction equation
[CH2:51]1[O:52][CH2:53][CH2:54][CH2:55]1.[CH3:1][c:2]1[cH:3][c:4]([NH:23][C:24]([O:25][c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)=[O:26])[cH:5][cH:6][c:7]1[O:8][c:9]1[n:10][cH:11][cH:12][cH:13][c:14]1-[c:15]1[n:16][c:17]([NH:21][CH3:22])[n:18][cH:19][cH:20]1.[CH3:33][N:34]1[CH2:35][CH2:36][N:37]([c:40]2[c:41]([NH2:50])[cH:42][c:43]([C:46]([F:47])([F:48])[F:49])[cH:44][cH:45]2)[CH2:38][CH2:39]1>>[CH3:1][c:2]1[cH:3][c:4]([NH:23][C:24](=[O:25])[NH:50][c:41]2[c:40]([N:37]3[CH2:36][CH2:35][N:34]([CH3:33])[CH2:39][CH2:38]3)[cH:45][cH:44][c:43]([C:46]([F:47])([F:48])[F:49])[cH:42]2)[cH:5][cH:6][c:7]1[O:8][c:9]1[n:10][cH:11][cH:12][cH:13][c:14]1-[c:15]1[n:16][c:17]([NH:21][CH3:22])[n:18][cH:19][cH:20]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 6932882-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)anilineHCID 58587930Phenyl 3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenylcarbamate

Product 1

HCID 58588304N-(3-methyl-4-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-N'-(2-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl)urea

Sources & evidence

ORD record
ord-4ca6700cbac74124af6d15bd36eace55
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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