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HRID69419

反应详情

EQUATION

反应方程式

HRID 69419 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccc(S(=O)(=O)O)cc1
HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：CCCCOc1ccc2c(c1)CCN(c1ccc(N3CCC4(C3)OCCO4)cc1)C2=O
HCID68992060

未命名化合物

PRODUCTS

生成物

1
结构：CCCCOc1ccc2c(c1)CCN(c1ccc(N3CCC(=O)C3)cc1)C2=O
HCID68988088

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A mixture of 6-butoxy-2-[4-(1,4-dioxa-7-azaspiro[4.4]non-7-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one (1.40 g), p-toluenesulfonic acid (57 mg) and acetone (40 mL) was boiled under reflux for 12 hours and then concentrated. The residue was partitioned between sodium carbonate solution and ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 378.48 (C23H26N2O3) was obtained in this way; MS (ESI): 379 (M+H+).

WORKUP

后处理

  1. temperatureunder reflux for 12 hours
  2. concentrationconcentrated
  3. customThe residue was partitioned between sodium carbonate solution and ethyl acetate
  4. customThe organic phase was dried
  5. concentrationconcentrated
  6. customThe product with the molecular weight of 378.48 (C23H26N2O3) was obtained in this way