HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidin-4-ol → 2-{3-Fluoro-4-[3-(4-hydroxy-piperidin-1-yl)-pyrrolidin-1-yl]-phenyl}-6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidin-4-ol | HCID 79341 | — |
| Reactant | HCID 68988102 | HCID 68988102 | — |
| Product | 2-{3-Fluoro-4-[3-(4-hydroxy-piperidin-1-yl)-pyrrolidin-1-yl]-phenyl}-6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one | HCID 57916756 | — |
Reaction Steps
According to Method J1, 2-[3-fluoro-4-(3-oxo-pyrrolidin-1-yl)-phenyl]-6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one was reacted with piperidin-4-ol. In this way the product was obtained with molecular weight 509.63 (C29H36FN3O4); MS (ESI): 510 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822495B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-ce3ddf2a57bb4261932db234a3f21685 |
| Source note | uspto-grants-2014_09 |