Piperidin-4-ol → 2-{3-Fluoro-4-[3-(4-hydroxy-piperidin-1-yl)-pyrrolidin-1-yl]-phenyl}-6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

HRID 69452Notes

Reaction equation

HRID 69452 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:14]2[CH2:23][CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19]([O:24][CH2:25][C@@H:26]4[CH2:30][CH2:29][CH2:28][O:27]4)[CH:20]=3)[C:15]2=[O:31])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:12][CH2:11][C:10](=O)[CH2:9]1.[NH:32]1[CH2:37][CH2:36][CH:35]([OH:38])[CH2:34][CH2:33]1>>[F:1][C:2]1[CH:3]=[C:4]([N:14]2[CH2:23][CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19]([O:24][CH2:25][C@@H:26]4[CH2:30][CH2:29][CH2:28][O:27]4)[CH:20]=3)[C:15]2=[O:31])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:12][CH2:11][CH:10]([N:32]2[CH2:37][CH2:36][CH:35]([OH:38])[CH2:34][CH2:33]2)[CH2:9]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 68988102HCID 68988102, compound

Product 1

HCID 579167562-{3-Fluoro-4-[3-(4-hydroxy-piperidin-1-yl)-pyrrolidin-1-yl]-phenyl}-6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

Procedure

According to Method J1, 2-[3-fluoro-4-(3-oxo-pyrrolidin-1-yl)-phenyl]-6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one was reacted with piperidin-4-ol. In this way the product was obtained with molecular weight 509.63 (C29H36FN3O4); MS (ESI): 510 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 509.63 (C29H36FN3O4)

Sources & evidence

ORD record
ord-ce3ddf2a57bb4261932db234a3f21685
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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